Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation
Abstract Orderly development of neuroendocrine and nervous system of mammals requires INSM1, a key regulator for cell differentiation.Ectopic expression of INSM1 is closely correlated with human neuroendocrine tumorigenesis, which makes INSM1 a reliable diagnostic biomarker and potential therapeutic target.To date, INSM1 is known as a transcription